Fowler Hollow Run is a stream in Perry County, Pennsylvania, in the United States. It is part of the Susquehanna River watershed as it is a tributary of Shultz Creek, which is a tributary of Sherman Creek, which flows into the Susquehanna. The drainage basin for Fowler Hollow Run is 5.59 square miles (14.48 km²) and enters Shultz Creek 3.90 miles (6.28 km) from its mouth on Sherman Creek.