The Goodhope River is a stream, 46 miles (74 km) long, on the Seward Peninsula in the U.S. state of Alaska. It heads about 5.3 miles (8.5 km) west-southwest of Cloud Lake and flows generally northeast to Goodhope Bay on Kotzebue Sound of the Chukchi Sea. The river mouth is about 27 miles (43 km) west of Cape Deceit and Deering in the Northwest Arctic Borough.