Slaughter Slough is a wetland in southwestern Minnesota, United States, so named for being the site of the Lake Shetek Massacre during the Dakota War of 1862. It is located in Murray County east of Lake Shetek. On August 20, 1862, about 40 Dakota people attacked the area's Euro-American settlers, killing 15 and taking a dozen women and children captive. 21 settlers escaped or survived the attack and made difficult journeys across the prairie to safety.