Etolin Island is an island in the Alexander Archipelago of southeastern Alaska, United States at (56°05′52″N132°21′37″W). It is between Prince of Wales Island, to its west, and the Alaska mainland, to its east. It is southwest of Wrangell Island. It was first charted in 1793 by James Johnstone, one of George Vancouver's officers during his 1791-95 expedition. He only charted its southwest and east coasts, not realizing it was an island. It was originally named Duke of York Island but was renamed by the United States after the Alaska Purchase.