Manhiça District is a district of Maputo Province in southern Mozambique. The principal town is Manhiça. The town of Manhica is notable for the research center CISM (Centro de Investigacao em Saude em Manhica) and the Manhica District Hospital, both institutions work closely together. The CISM receives several international students each year, especially from Spain, and so there are several expats living in Manhica at any given time.