Chiautempan (also: Santa Ana Chiautempan) is a city and its surrounding municipality of the same name located in the south-central part of the Mexican state of Tlaxcala. The city serves as the municipal seat of the municipality, which covers an area of 66.21 km² (25.56 sq mi). At the 2005 census it had a population of 46,776 inhabitants, the fourth-largest community in the state in population (after Villa Vicente Guerrero, Apizaco, and Huamantla).