Kampong Siem District (Khmer: ស្រុកកំពង់សៀម) is a district (srok) located in Kampong Cham Province, Cambodia. The district surrounds the provincial capital Kampong Cham City. The administrative center of the district locates not far from the Provincial capital of Kampong Cham in Ampil Leu Village, Ampil Commune about 3 km west from the center of Kampong Cham city on National Highway 7 and is 120 kilometres by road from Phnom Penh.