Chittoor district ( pronunciation ), also known as Chittur, is a district in Rayalaseema region of Andhra Pradesh, India. The district headquarters is Chittoor and the largest city is Tirupati. The district has a population of 4,170,468 according to 2011 census of India. Chittoor district has many major temples including Tirupati, Kanipakam and Sri Kalahasti temples. It lies in the Poini river valley of southernmost Andhra Pradesh along the Chennai - Bangalore section Chennai-Mumbai highway.