Afdera (Afar Afxeera) is one of the woredas in the Afar Region of Ethiopia. It is named after the saline Lake Afdera, located in the southern part of the Afar Depression. Part of the Administrative Zone 2, Afdera is bordered on the southwest by the Administrative Zone 4, on the west by Erebti and Abala, on the north by Berhale, on the northeast by Eritrea, and on the southeast by Administrative Zone 1. The largest towns of this woreda is Afdera.