Asegede Tsimbela is one of the woredas in the Tigray Region of Ethiopia. Part of the Semien Mi'irabawi Zone, Asegede Tsimbela is bordered along the south by the Tekezé River which separates the woreda on the south from Tselemti and to the west by the Mi'irabawi Zone, then on the northwest by Tahtay Adiyabo, on the north by La'ilay Adiyabo, on the northeast by Tahtay Koraro, and on the east by Medebay Zana.