Puyehue (Spanish pronunciation: [puˈʝewe]) is a commune in Chile located in Osorno Province of Los Lagos Region. It is bordered to the south by Rupanco Lake, to the east by the Andes and Argentina, to the north by Puyehue Lake and to the west by Osorno commune. Cardenal Antonio Samoré Pass that links the Los Lagos Region to Argentina lies in the eastern tip of the commune. The comune is administered by Entre Lagos, the main town in Puyehue.