The Spitalgasse is one of the streets in the Old City of Bern, the medieval city center of Bern, Switzerland. It is part of the Äussere Neustadt which was built during the third expansion from 1344 to 1346. The eastern end is at Waisenhausplatz and Bärenplatz while the western end is at Bahnhofplatz near the Church of the Holy Ghost.