Cayuga Secondary School is a secondary school located at 70 Highway 54, Cayuga, Ontario, Canada. It is part of the Grand Erie District School Board. Cayuga Secondary School opened in 1963 under the name Cayuga Technical and Commercial High School since it did not offer a grade 13 program. It earned secondary school status in 1970. The students come from J. L. Mitchener, Rainham Central, Seneca Central Seneca Unity and Oneida Central public schools, Caledonia as well as some students from the Six Nations Reserve and from the Catholic elementary school St. Stephen's. The school currently has about 600 students enrolled.