Gananoque (/ˌɡænəˈnɒkweɪ/ GAN-ə-NOK-way) is a town in the Leeds and Grenville area of Ontario, Canada. The town had a population of 5,194 year-round residents in the Canada 2011 Census, as well as summer residents sometimes referred to as "Islanders" because of the Thousand Islands in the Saint Lawrence River, Gananoque's most important tourist attraction. The Gananoque River flows through the town and the St.