The Innu call it "Mishtashipu", "Great River". As they have done for thousands of years, they continue to use the river to reach their northern hunting and fishing grounds. Large parts of the river were also protected by private fishing clubs. There were recent attempts to develop hydroelectric projects on the Moisie. However, in 2003, the Quebec government protected a large part of the river's watershed as an aquatic reserve. This prevents activities such as logging, mining and power projects, but permits traditional uses such as hunting and fly-fishing.