uMkhanyakude is the northernmost of the 11 districts of the KwaZulu-Natal province of South Africa. Its seat is Mkuze. It is a very rural district, the largest town being Mtubatuba in the south, with Hluhluwe, Mkuze, Jozini, Kwangwanase and Ingwavuma further to the north. The majority of its 573,353 people speak IsiZulu (2001 Census).