St. Regis Mohawk Reservation is a Mohawk Indian reservation in Franklin County, New York, United States. It is also known by its Mohawk name, Akwesasne. The population was 3,288 at the 2010 census. The reservation is adjacent to the Akwesasne reserve in Ontario and Quebec. The Mohawk consider the entire community to be one unit. The reservation contains the village of St. Regis and borders the village of Hogansburg in the Town of Bombay.