Southampton is a neighborhood in Saint Louis, Missouri. Located in the southwestern reaches of the city, its borders are Chippewa Street (Route 366) (formerly U.S. Route 66) on the north, Hampton Avenue on the west, Eichelberger Street on the south, and South Kingshighway Boulevard on the east. It is a quiet neighborhood that was historically populated by Germanic immigrants. Typical residential architectural styles include "Hansel and Gretel", Neo-Tudor, Arts & Crafts, and Foursquare bungalows. Although the earliest housing is dated from 1905-1915, most of the houses were built from the 1920s to the late 1930s and are primarily brick and stone. A portion of the neighborhood was platted by an Anglophile who used English (and one Scottish) locations to name the streets and avenues (Devonshire, Lansdowne, Nottingham, Sutherland).