The unincorporated community of Panoche is located along Panoche Road in the southern, rural part of San Benito County, California, United States. The community is about 2.7 driving miles east of County Route J1. The county seat, Hollister, is roughly 35 miles (56 km) straight-line distance. The Fresno County line is about 3.7 miles (6.0 km) distant to the northeast.