The Charterhouse of Jerez de la Frontera (Spanish: la Cartuja de Jerez de la Frontera) or Charterhouse of Santa María de la Defensión (Spanish: la Cartuja de Santa María de la Defensión; also la Cartuja de Nuestra Señora de la Defensión) is a monastery in Jerez de la Frontera, Cádiz, Spain. Its architecture is of a Late Gothic style, corresponding to the start of construction in the 15th century, with Baroque aspects dating from the 17th century. The building, completed in the 17th century, has been designated by the Spanish government as an Historic-Artistic Monument (Monumento Histórico-Artístico).