Santaliestra y San Quílez (Spanish: [santaˈljestɾa i saŋ ˈkileθ]) or Santa Llestra i Sant Quilis (Catalan: [ˈsantə ˈʎɛstɾəj saŋ ˈkilis], locally: [ˈsanta ˈʎɛstɾaj saŋ ˈkilis]) is a municipality located in the province of Huesca, Aragon, Spain.