Amacayacu National Natural Park (Spanish: Parque Nacional Natural Amacayacu) is a national park located along the Amazon River in the Amazonas Department in the south of Colombia. The park was created in 1975. The word "Amacayacu" means "River of the Hamocs" in the indigenous language Quechua. The Ticuna people currently inhabit a part of the park. The park comprises 4,220 square kilometres of jungle, a significant portion of which is annually flooded by the Amazon River during the wet season.