Cayoosh Creek is a northeast-flowing tributary of the Seton River in the Canadian province of British Columbia. The name Cayoosh Creek remains on the bridge-sign crossing the stream on BC Highway 99 and continues in use locally to refer to the final reaches of the Seton River, formerly Seton Creek, which prior to the renaming ending at the confluence with Cayoosh Creek. The creek is the namesake of Cayoosh Creek Indian Reserve No.