Panotla Municipality is a municipality in Tlaxcala in south-eastern Mexico. It is located about four km to the west of the city of Tlaxcala. Panotla contains a number of notable churches from different eras of its history. The San Nicolás de Bari church was dedicated in 1796. It has an ornate baroque facade framed by an arch and a two level bell tower. The baroque elements of both are made with mortar and include estipite columns as well as floral, animal and human motifs. These face onto a large atrium which is bordered by a wall. The interior of the church consists of a single nave with Neoclassical altarpieces and an organ from the 17th century. The Nuestra Señora de la Defensa Sanctuary is located in the community of San Ambrosio Texantla was constructed between the 17th and 18th centuries. The exterior has an octagon dome and a tower with merlons on its corners.