Rancho Guajome was a 2,219-acre (8.98 km²) Mexican land grant in present day San Diego County, California given in 1845 by Governor Pío Pico to Andrés and José Manuel, Indians. The name comes from a Luiseño phrase involving the word "frog", likely wakhavumi "frog pond" or waxáawu-may "little frog". The grant was south of San Luis Rey River and Rancho Monserate and north of present day Vista.