The Blood Run Site is an archaeological site on the border of the US states of Iowa and South Dakota. The site was essentially populated for 8,500 years, within which earthworks structures were built by the Oneota Culture and occupied descendant tribes such as the Ioway, Otoe, Missouri, and shared with Quapaw and later Kansa, Osage, Omaha (who were both Omaha and Ponca at the time) people.