Khon Kaen (Thai: ขอนแก่น, pronounced [kʰɔ̌ːn kɛ̀n] or  [kʰɔ̌n kɛ̀n]) is one of the four major cities of Isan, Thailand, also known as the "Big 4 of Isan", the others being Udon Thani, Khorat, and Ubon Ratchathani.