The municipality and town of Totatiche is located in the northern extreme of the state of Jalisco, Mexico between 21°48’30” and 22°06’00” latitude north and 103°20’00” and 103°34’00” longitude east at a height of 1,751 meters (5,745 ft) above sea level. The municipality is bordered on the north and southeast by the state of Zacatecas.