Galena is the largest city in and the county seat of Jo Daviess County, Illinois, with a population of 3,429 at the 2010 census. A 581-acre (235 ha) section of the city is listed on the National Register of Historic Places as the Galena Historic District. It is named for the mineral galena, which was mined by Native Americans in the area for over a thousand years. Owing to these deposits, Galena was the site of the first major mineral rush in the United States. The first American settler arrived in 1821, and by 1828, the population was estimated at 10,000. The city emerged as the largest steamboat hub on the Mississippi River north of St. Louis, Missouri. Galena was the home of Ulysses S. Grant and eight other Civil War generals.